Quince Therapeutics Selects Option Care Health as Specialty Infusion Therapy Provider for Administration of Lead Asset eDSP

August 7, 2025   (PDF Version)

Provides access to broad-reaching nationwide network of specialty pharmacy and ambulatory infusion suites across the U.S.

SOUTH SAN FRANCISCO, Calif. & BANNOCKBURN, Ill.–(BUSINESS WIRE)–Aug. 7, 2025– Quince Therapeutics, Inc. (Nasdaq: QNCX), a
late-stage biotechnology company dedicated to unlocking the power of a patient’s own biology for the treatment of rare diseases, today announced
that it has formed a strategic relationship with Option Care Health, Inc. (Nasdaq: OPCH), the nation’s largest independent provider of home and
ambulatory infusion services, to support the commercial development and efficient launch of Quince’s lead asset, encapsulated dexamethasone
sodium phosphate (eDSP) in the U.S., assuming positive study results and subsequent regulatory approval.

The strategic relationship will leverage Option Care Health’s robust network of specialty pharmacies and ambulatory infusion suites to provide for the
administration of eDSP in an effective and efficient way while delivering this innovative treatment to patients. With a national footprint of more than 90
full-service pharmacies and 180-plus ambulatory infusion suites located across the U.S., Option Care Health is well positioned to dramatically
enhance Quince’s ability to provide patients with Ataxia-Telangiectasia (A-T) access to eDSP treatment, including greater geographic flexibility to
match patient locations and eDSP administration needs, an improved and standardized patient journey with higher control and consistency across
eDSP administration sites, the benefit of contracting with a single provider versus multiple individual academic centers of excellence, and scalability to
treat patients in additional targeted indications such as Duchenne muscular dystrophy (DMD). Additionally, the engagement will be supported by
Option Care Health’s comprehensive suite of enhanced service capabilities, including third-party logistics (3PL) and inventory distribution
management, program management, customized patient registration and hub support, clinician-delivered services, physician reporting, and data
collection and reporting.

Charles Ryan, J.D., Ph.D., Quince’s President who manages several departments including Commercial, said, “We are very pleased to enter into a
strategic partnership with Option Care Health that is designed to greatly improve the patient journey while also establishing an effective and efficient
commercialization pathway for our highly innovative lead asset, eDSP. Option Care Health is a strong partner with a deep understanding of the
complexities of rare disease treatments. We look forward to working together to leverage all the benefits of its nationwide integrated care platform of
specialty pharmacy, infusion suites, and nursing services for the benefit of patients with A-T.”
Eric Daugherty, Senior Vice President, Biopharma Relations, of Option Care Health, said, “As a leading provider in the treatment of rare and orphan
diseases, our organization is honored to have been selected by Quince as its specialty infusion therapy partner. Together, we are committed to making
their novel eDSP asset accessible for patients with A-T across the U.S. as Quince readies for commercial launch and ultimately looks to engage
providers and payers in a seamless way.”

About Quince Therapeutics

Quince Therapeutics, Inc. (Nasdaq: QNCX) is a late-stage biotechnology company dedicated to unlocking the power of a patient’s own biology for the
treatment of rare diseases. For more information on the company and its latest news, visit www.quincetx.com and follow Quince on social media
platforms LinkedIn, Facebook, X, and YouTube.

Forward-looking Statements

Statements in this news release contain “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995 as
contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are
subject to the “safe harbor” created by those sections. All statements, other than statements of historical facts, may be forward-looking statements.
Forward-looking statements contained in this news release may be identified by the use of words such as “believe,” “may,” “should,” “expect,”
“anticipate,” “plan,” “believe,” “estimated,” “potential,” “intend,” “will,” “can,” “seek,” or other similar words. Examples of forward-looking statements
include, among others, statements relating to the benefits of the strategic partnership with Option Care, including improved patient access and other
commercial development activities; current and future clinical development and regulatory approval of eDSP, including for the potential treatment of
Ataxia-Telangiectasia (A-T), Duchenne muscular dystrophy (DMD), and other potential indications; the strategic development path for eDSP; planned
regulatory agency submissions and clinical trials and timeline, prospects, and milestone expectations; and the potential benefits of eDSP and the
company’s market opportunity. Forward-looking statements are based on Quince’s current expectations and are subject to inherent uncertainties,
risks, and assumptions that are difficult to predict and could cause actual results to differ materially from what the company expects. Further, certain
forward-looking statements are based on assumptions as to future events that may not prove to be accurate. Factors that could cause actual results to
differ include, but are not limited to, the risks and uncertainties described in the section titled “Risk Factors” in the company’s Quarterly Report on Form
10-Q filed with the Securities and Exchange Commission (SEC) on May 13, 2025, and other reports as filed with the SEC. Forward-looking statements
contained in this news release are made as of this date, and Quince undertakes no duty to update such information except as required under
applicable law.

View source version on businesswire.com: https://www.businesswire.com/news/home/20250807215445/en/

Media & Investor Contact:
Stacy Roughan
Quince Therapeutics, Inc.
Vice President, Corporate Communications & Investor Relations
ir@quincetx.com

Source: Quince Therapeutics, Inc.

In 2022, I graduated from nursing school with dreams of starting my career as a nurse. However, life had other plans. I was diagnosed with gastroparesis, a condition that made it impossible for me to work and pursue my passion. As my condition worsened, I had to put my career on hold to focus on my health.

Initially, my local clinicians recommended jejunal feedings, which I tolerated well at first. However, after my J-tube surgery, my condition began to deteriorate, and eventually I became severely malnourished. I was surviving on a mere 500 calories a day, leaving me too weak to perform even the simplest tasks. My mom had to help me with everything, including bathing. Living in a two-story home became a daily struggle, as I had to crawl up the stairs, feeling my body slowly giving up.

My local registered dietitian recommended Parenteral Nutrition (PN) and sent the order. We were then referred to Option Care Health (OPCH). I was scared to start PN, but my OPCH dietitian reassured me, saying, “Just because you’re on PN doesn’t mean your life is over. The goal is to give you back more of your life than before.” Her words stuck with me, offering hope during a difficult time.

Due to my blood sugar issues, I’m on 23-hour PN feeds and carry a backpack that has become a part of me. Despite these challenges, my OPCH team has been incredible. My registered dietitian and pharmacist have truly been lifesavers. I continue to speak with my OPCH registered dietitian weekly because she genuinely cares about my well-being and supports me through every step of my journey.

Thanks to the unwavering support of my Option Care Health team and my local registered dietitian, I am back to work and feeling so much better. I wholeheartedly recommend Option Care Health to anyone in need. They have played a crucial role in my recovery, and I am forever grateful for their dedication and care.

Gastroparesis refers to a delay in emptying stomach contents.  Symptoms often include feeling full after eating a meal, or even a small amount of food, as well as nausea, vomiting, bloating or abdominal pain. The causes of gastroparesis may include diabetes mellitus, complications after surgery, kidney disease, certain medications, thyroid disorders, cancer, among others.

The following tips are intended to reduce symptoms and help maintain adequate nutrition.

Fluids

• Stay hydrated. Most adults need 6-10 cups of water per day. Sip slowly throughout the day.
• Drink fluids with meals, however; be sure not to fill up on liquids
• Avoid carbonated beverages as they can cause bloating

Otro

• Avoid alcohol as it can affect stomach emptying
• Foods that are acidic, spicy, or contain caffeine or mint may increase acid reflux
• Keep blood sugars under control if you have diabetes
• Keep a food diary to track your intake and find foods that are best tolerated
• Exercise may increase stomach emptying and reduce symptoms. Walking after meals is suggested.

See below for help in choosing more optimal foods from each food group:

Gastroparesis Sample Menus

Please visit Restore+ to learn more about the nutrition support services offered by Option Care Health.

*This material is for informational purposes only. It does not replace the advice or counsel of a healthcare professional. Please consult with your Registered Dietitian for more detailed, individualized information.

Dining out at restaurants is a nice treat but also challenging when trying to stick with your therapeutic diet, especially with gastrointestinal diseases. Most restaurants have menus and nutritional information available online. Restaurants are not required to have nutrition information available if they have less than 20 locations. Follow these tips to navigate eating out if you have specialized nutrition needs.

GENERAL TIPS:

• Research the menu online
• Pick a cuisine you tolerate
• Ask server for nutritional information or ingredients if not listed on the menu
• Do NOT be afraid to ask to customize the meal or ask for specific changes
• Communicate with wait staff if you have a food allergy or intolerance
• HAVE A PLAN AND STICK WITH IT!

Short bowel syndrome (SBS), or intestinal failure, is a condition in which your body is unable to absorb enough nutrients from foods and fluids you consume. This can occur after a surgical resection or damage to your intestines. Symptoms and absorption vary by individual based on the amount and health of the remaining intestine. Symptoms of SBS can include diarrhea, dehydration, electrolyte abnormalities, and weight loss.  

The following tips are intended to maximize absorption, improve your nutritional status and reduce dependence on parenteral nutrition. 

• Mealtime
  • Eat small, frequent meals (6-8 per day)
• Foods
  • Eat protein at all meals: eggs, creamy peanut butter, chicken, fish, beef, tofu
  • Choose complex carbohydrates such as bread, pasta, rice, and potatoes
  • Limit raw vegetables to small amounts
  • Avoid fruits with skin or edible seeds
  • Limit raw fruits to very small portion twice a day
  • Increase your soluble fiber to thicken output with foods such as bananas, applesauce, rice, oatmeal or use of soluble fiber supplements
  • Avoid high fat foods such as fried foods if your colon is intact
  • Use caution with dairy products – lactose intolerance is common with SBS
  • Avoid concentrated sweets such as candy, desserts, and juice
  • Avoid foods artificially sweetened with sorbitol or mannitol (Splenda® is okay)
• Fluids
  • Drink isotonic fluids (with electrolytes), ideally oral rehydration solutions (see recipes below)
  • Do not drink fluids with meals as it increases how quickly food passes through
  • Limit to 4 oz. fluid during your meal to allow your food to be best absorbed
  • Drink ½ hour before or 2 hours after eating
  • If you do not have your colon, your fluid losses will be higher
• Otro
  • If prescribed by your doctor, take antidiarrheal medication ½ hour before meals
  • Salty foods such as pretzels or soups are usually well tolerated and help absorb fluid
  • Avoid caffeine and alcohol

See below for help in choosing more optimal foods from each food group:

**For homemade ORS, discard after 24 hours if not consumed **Visit for more recipes: https://optioncarehealth.com/patients/resources/sbs-friendly-recipes

SBS Sample Menu

Please visit Restore+ to learn more about the nutrition support services offered by Option Care Health.

*This material is for informational purposes only. It does not replace the advice or counsel of a healthcare professional. Please consult with your Registered Dietitian for more detailed, individualized information.

Gillian was just 11 years old when she began treatment for multiple complex chronic illnesses. As a teenager, she was diagnosed with gastrointestinal (GI) motility disorder and gastroparesis, which led to long-term, severe malnutrition.

“It was really hard missing out on so many activities growing up. I was prescribed various medications and tube feedings, but nothing helped long term. By early adulthood my symptoms worsened so I had to withdraw from college and take an extended medical leave from my job,” she said.

From 2015 to 2018, Gillian’s health progressively declined. “I was on tube feeds and other intravenous (IV) medications at the time. I began losing weight again, my neurological function was declining and I couldn’t speak or walk.” As Gillian’s health continued to decline, she found the strength to advocate for herself and build upon her excellent team of healthcare providers.

Gillian was put on total parenteral nutrition (TPN) in 2018, managed by Option Care Health. “This was my turning point. Today my labs are perfect and my cognitive function is back to normal. My weight has stabilized and I’m back to living life. I owe so much of my progress to my Option Care Health team.” Gillian continued, “My registered dietitian (RD) is amazing. During the initial COVID outbreak, I was struggling with my health and I couldn’t reach my doctors, but my Option Care Health RD was there every time I reached out. I got the help I needed and I owe it all to her.”

She claims that her Option Care Health team including her pharmacist and pharmacy technician go above and beyond expectation. “Other companies and even providers don’t always focus on how the patient needs to be living their best quality of life during treatment. My team at Option Care Health set up my deliveries in the evening to accommodate my work schedule. They also deliver them upstairs to me because I’m unable to carry them. My pharmacist and tech were so helpful this summer. They were able to find a way for me to go on vacation by switching around my infusions and supplies. Thanks to their help, I was able to go on my first trip since 2015! They are really focused on me as a person, not just a patient.”

Her message to her Option Care Health team is one of gratitude, “I just want them all to know how appreciative I am. They have and continue to be a key part of my recovery and I couldn’t be more grateful.” Gillian is thriving and living her best quality of life. She’s working, volunteering and spending as much time as possible with family and friends.

Learn more about malnutrition and join us in spreading awareness this ASPEN Malnutrition Awareness Week*, September 19th-23rd: ASPENMAW22 

Semana de Concientización sobre la Desnutrición™ es una marca de la American Society for Parenteral & Enteral Nutrition (ASPEN). Se utiliza con permiso de la ASPEN.  

As a leading healthcare provider, we recognize our role and our responsibility to protect the health and safety of our patients, customers, team members and community. Option Care Health is mandating all leaders be fully vaccinated by September 30, 2021 and all patient and customer-facing team members be fully vaccinated by October 15, 2021.

“Our mission is to transform healthcare while delivering hope to our patients and their families,” said John Rademacher, Chief Executive Officer. “We believe our single largest contribution to eradicating COVID-19 is through vaccination. By receiving the vaccine, we are becoming a part of the solution. Each one of us at Option Care Health plays a critical role in our purpose of providing extraordinary care that changes lives.”

Option Care Health complies with applicable federal, state and local laws and will evaluate exceptions to the vaccine requirement due to a medical condition or strongly held religious beliefs.

Hace cuatro años, Sherry Hambly, de 56 años, desarrolló un doloroso sarpullido que constantemente se sentía como si tuviera una terrible quemadura solar. Su piel le quemaba cada vez que se lavaba las manos o tomaba una ducha y sus músculos estaban débiles. Después de un largo viaje en busca de respuestas, le diagnosticaron dermatomiositis, un trastorno autoinmunitario. Ahora recibe inmunoglobulina intravenosa (IVIG) en la sala de infusión de Option Care Health en Troy, Míchigan, y está agradecida de haber recuperado su vida.

Antes de encontrar el diagnóstico y el tratamiento adecuados, Sherry se sentía tan incómoda que tenía que tomar analgésicos todos los días y apenas podía realizar su trabajo como contadora debido a su debilidad. No dormía bien y estaba demasiado cansada para disfrutar de las cosas que le producían alegría, como jugar con sus nietos, jugar golf, jugar a los bolos y hacer yoga.

“Amo a los empleados de la sala de infusión de Troy porque nunca tengo que mover un dedo; ellos se encargan de todo y se aseguran de que mi plan de atención sea personalizado”, dijo Sherry, de Rochester Hills, Míchigan.

Al principio, estaba tomando hidroxicloroquina, una dosis alta de esteroides y un fármaco contra el rechazo. Su prescripción original de IVIG incluía infusiones de IVIG de cuatro horas tres días seguidos una vez al mes, pero al final del mes los beneficios se terminaron y no tenía la energía para ir a la oficina. El equipo de Option Care Health trabajó con Sherry, su médico y farmacéutico para diseñar un plan de atención que funcionara mejor para ella y ahora recibe las infusiones dos días a la semana cada dos semanas.

“Ha marcado una gran diferencia”, dijo. "Ya no tomo pastillas para el dolor y dejé por completo todos los esteroides en los que confiaba para mantenerme en movimiento, porque mi tratamiento con IVIG está ayudando de manera espectacular".

Vive con su esposo, su hijo y sus dos nietos. Ahora que ha recuperado su energía, puede ayudar a su nieto de 11 años con la educación en casa y cuidar a su nieta de 16 meses. Ha vuelto a jugar golf y a practicar yoga, y puede realizar su trabajo al máximo de su potencial.

“Me gusta mucho la sala de infusiones, es agradable estar en tu propio pequeño espacio durante el COVID-19, la habitación tiene ventanas, sillas cómodas y una cocina donde puedo calentar mi café. Es tranquilo e incluso puedo trabajar mientras estoy allí", dijo. "El personal siempre hace todo lo posible para asegurarse de que estemos seguros y cómodos".

Con frecuencia enferma de neumonía, bronquitis y otras infecciones graves, Cambria Hooven, de 35 años, limitó su contacto con la gente y no salía mucho de su casa. Después de que descubrió finalmente que la razón de su enfermedad casi constante era un sistema inmunológico debilitado debido a una inmunodeficiencia variable común (IDVC), ella comenzó a recibir inmunoglobulina intravenosa (IVIG) en casa a través de Option Care Health. Se sintió libre para salir más y socializar, pero después llegó la pandemia de COVID-19.

Debido a que Cambria tenía miedo de arriesgarse a recibir visitas en su casa, su enfermero de Option Care Health, Kola, ideó un plan. Sugirió que recibiera tratamientos en la sala para terapia de infusión de Option Care Health Langhorne en donde él trabaja y que se encuentra a 35 minutos en automóvil de la casa de Cambria en Filadelfia.

“Me inquietaba la idea de ir porque no estaba convencida de salir a ningún lugar durante esta pandemia, así que él me envió un video de la sala antes de mi primera cita, en este, él hacía un recorrido por todo el lugar y me mostraba exactamente por qué puertas entrar”, dijo Cambria, cuyos ojos se llenan de lágrimas al recordarlo. “Kola ha sido mi enfermero durante dos años y es como mi familia. ¡No sé qué haría si él no estuviera en mi vida!"

Ahora recibe sus tratamientos mensuales de cuatro horas en una habitación limpia y desinfectada, que tiene su propio sillón cómodo y grandes ventanales. Ya que se queda en casa durante la pandemia, realmente disfruta de recibir sus infusiones mensuales. "Es un pequeño centro de retiro", dice Cambria.

Cambria se siente aliviada de tener finalmente un diagnóstico y de recibir tratamiento. Durante años, vio a un médico tras otro para tratar de averiguar por qué siempre estaba enferma. Hace ocho años, le extirparon el apéndice, contrajo una infección sanguínea grave y pasó 33 días en el hospital, sin saber si sobreviviría. Decidida a llegar al fondo de su problema, solicitó un permiso para ausentarse de su trabajo como trabajadora social en bienestar infantil con el fin de realizarse diferentes pruebas.

Finalmente vio a un especialista en inmunología que diagnosticó su afección y le recetó IGIV. Como resultado, ya no la han hospitalizado desde entonces. En un principio, ella comenzó a autoinfundirse en casa, pero no se sentía cómoda haciéndolo. Option Care Health recomendó que un enfermero fuera a su casa para administrarle las infusiones y así fue como conoció a Kola.

Ahora que está recibiendo tratamiento, Cambria se siente más saludable y puede realizar su trabajo de forma remota como trabajadora social, a menudo desde la sala para terapia de infusión de Langhorne.

“Sé cómo mantenerme a salvo y el tratamiento que recibo en Option Care Health me ayuda a no tener que vivir con miedo y aislada. Puedo salir a caminar y viajar de forma segura”, dijo. “Es grandioso ir a la sala de Langhorne, que es segura y está limpia, además siento un profundo respeto por los enfermeros y sus familias. Son muy considerados".

Lo único que Abbi Tucker desea es ser una adolescente normal y disfrutar tocando música, pero cuando tenía 13 años, fuertes dolores de cabeza por migraña y terribles dolores de estómago, que resultaron en una pérdida de peso de 50 libras, arruinaron sus esperanzas por un tiempo. Después de numerosas pruebas y consultas con médicos, le diagnosticaron la enfermedad de Crohn, una enfermedad inflamatoria intestinal. Su vida ha vuelto a la normalidad ahora que recibe infusiones de terapia para tratar trastornos inflamatorios crónicos en la sala de infusión de Troy de Option Care Health.

“Cuando comencé a recibir tratamiento, mi vida cambió”, dice Abbi, ahora de 16 años, de Marysville, Míchigan. "Volví a subir de peso y finalmente pude concentrarme en la escuela y divertirme de nuevo".

Cuando Abbi comenzó a experimentar graves problemas de salud, ella y su familia estaban asustados y ella se sentía terrible. Sus síntomas la hacían perder al menos un día de clases a la semana y le resultaba difícil mantenerse al día con sus estudios. No podía pasar tiempo con sus amigos, tocar o dar clases de piano, e incluso perdió el apetito.

Ahora, con un plan de tratamiento en curso, ha vuelto a sus actividades, lo que incluye la práctica en una banda como baterista júnior, pasar tiempo con amigos y tocar música en su iglesia. Comer también es gratificante, aunque se mantiene alejada de las comidas grasosas y picantes, así como de las palomitas de maíz.

Abbi originalmente recibía su terapia de una hora cada siete semanas en el hospital. Cuando surgieron problemas con el seguro médico que requirieron un cambio a una compañía de terapia de infusión, ella y su familia eligieron Option Care Health y no podrían estar más felices con su elección.

"AMO a los enfermeros que trabajan ahí", dijo. “Es muy difícil que me logren sacar sangre, lo que hace que el proceso sea doloroso. Uno de mis enfermeros de infusión de Option Care Health me hizo una almohadilla térmica y la uso cada vez que me extraen sangre. Es increíble".

Antonette, la recepcionista del centro, llama para recordarle a su familia las próximas citas y el personal sabe que debe buscar la camioneta roja del padre de Abbi cuando va a dejarla. Es bombero y paramédico con preparación médica, lo que tranquiliza a su familia.

Le gusta recibir atención en la sala para terapia de infusión en lugar de en casa porque ocasionalmente ha tenido reacciones adversas. Toma Benadryl y un esteroide antes de cada tratamiento, lo que ayuda, pero le da tranquilidad saber que las enfermeras de Option Care Health están ahí en caso de que comience a tener problemas. También aprecia la privacidad de las salas.

“El personal siempre me hace sentir como en casa y que mi salud es su prioridad número uno”, dijo Abbi. "La terapia de infusión realmente me ha cambiado la vida y ahora puedo hacer lo que haría una típica joven de 16 años todos los días".